CPC Simulator

An individual tool for proposing the purification method on CPC with the most effective solvent system and the highest yield.

The CPC Simulator tool, as the part of the CPC Modeler and also as an individual tool, lets you find the most effective CPC purification method and evaluate the productivity of your compound of interest. The core of the CPC Simulator consists of a database containing extensive data from scientific literature and a search engine that offers you purification methods tested with CPC. There are only two things needed to use the CPC Simulator: the partition coefficient and the composition of the crude material. The simulator lets you select between predefined instruments and separation modes. Several important factors affecting peak shape and separation performance are taken into account in the model calculations to improve the simulator's predictivity. These include high concentration, low solubility, and other factors. By changing a parameter's value, you get instant feedback on how it affects separation. As a result, the tool can give you the elution profile with a more precise estimation than a single partition coefficient value.

Features

Find the most effective solvent system and purification method for CPC

Only two input data needed for operation: partition coefficient and composition of the crude material

Model, test and optimize purification performance

Estimate the elution profile with precision

Test thousands of compounds in silico to find future directions

Rely on a library of data from scientific literature, combined with an intelligent search engine, developed by chemists and chemoinformatic experts

Benefits

Quick and cost-effective computational tests instead of slow, cumbersome and expensive experimentation

A library of extensive, well-researched and evolving data, instead of time-consuming literature search

Prediction-based results to support decision making

About RotaChrom

RotaChrom has developed the world’s first commercially available industrial scale centrifugal partition chromatography (CPC) platform. This technology revolutionized the purification industry by providing cost-effective commercial scale chromatographic solutions to Partners all over the world. RotaChrom is currently working with a broad array of industries including pharmaceutical, nutraceutical, health and beauty, and botanical companies, CROs, CDMOs, research and academia, and more in the Americas, Europe, China, India, and Asia.

More about RotaChrom

Check out our subscription plans to decide which would suit your needs. In order to subscribe to our Free plan you only need to register, just click on the button below. If you want to upgrade to our Standard plan you can apply from the application once you've logged in.

Free

  • Limited access to our partition database

  • Limited access to compound details

  • Search by compound name, SMILES or CAS number

Standard

  • Unlimited access to our database

  • Search by compound name, SMILES or CAS number

  • Search by chemical structure and similarity (by Chemaxon)

  • List all compound details

  • Simulate CPC separation

Contact us

If you would prefer to talk to one of our experts, please send us a message!